Products for Research Use Only
RegisterLogin

TIMP3 Antibody

CAT: 0223-33-214Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-33-214Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM) . An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP’s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
NCBI Gene ID
7078
Swiss Prot
P35625
Host
Rabbit
Reactivity
Human, Mouse, Rat, Horse, Bovine, Dog
Immunogen
Amino acids 175-211 of human TIMP3 Ab was used as the immunogen for this antibody (100% homologous in cow, dog and horse, and 94% homologous in mouse and rat) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
Protein A affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TIMP3 antibody to be titered up or down for optimal performance.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. 2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Symbol
TIMP3
NCBI Official Name
Metalloproteinase inhibitor 3
NCBI Organism
Homo sapiens
Other Product Names
Metalloproteinase inhibitor 3, Protein MIG-5, Tissue inhibitor of metalloproteinases 3, TIMP-3, TIMP3
Tested Applications
WB, Flow, IHC, IP, IF
Physical Properties
Liquid

Related Products

CatalogName
42-914TIMP1 Antibody
16-606TIMP2 Antibody
15-251TIMP1 Antibody
22-204TIMP4 Antibody
62-416TIMP1 Antibody
55-060TIMP4 Antibody
55-700TIMP1 Antibody
16-119TIMP2 Antibody
33-734TIMP2 Antibody [SPM356]
38-215TIMP-1 Antibody

Alternative Products

CatalogName
70R-13761TIMP3 antibody

Popular Products