TIMP2 Antibody

• Background:

  This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

• NCBI Gene ID:

  7077

• Swiss Prot:

  P16035

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TIMP2 (NP_003246.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  A-549

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 26kDa

• Fragment:

  IgG

• Symbol:

  TIMP2

• Positive Control 2:

  293T

• Positive Control 3:

  Mouse spleen

• Positive Control 4:

  Mouse lung

• Positive Control 5:

  Mouse brain

• Positive Control 6:

  Rat spleen

• NCBI Official Name:

  TIMP metallopeptidase inhibitor 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TIMP2, Metalloproteinase inhibitor 2, TIMP-2, CSC-21K

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid