Dnmt3b Antibody

• Background:

  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome.

• NCBI Gene ID:

  1789

• Swiss Prot:

  Q9UBC3

• Accession Number:

  Q9UBC3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Dnmt3b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-417 amino acids from human Dnmt3b.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  96 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DNMT3B

• NCBI Official Name:

  DNA (cytosine-5) -methyltransferase 3B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Okano, M., et al., Cell 99 (3) :247-257 (1999) . Yin, B., et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 21 (6) :431-438 (1999) . Okano, M., et al., Nat. Genet. 19 (3) :219-220 (1998) .

• Other Product Names:

  DNA (cytosine-5) -methyltransferase 3B, Dnmt3b, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, MHsaIIIB, DNMT3B

• Tested Applications:

  WB, IHC-P

• Protein ID:

  17375667

• Physical Properties:

  Liquid