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DNMT3A Antibody

CAT: 0223-58-155Size: 400 µLDry Ice: NoHazardous: No
CAT#: 58-155Size: 400 µL
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
NCBI Gene ID
1788
Swiss Prot
Q9Y6K1
Accession Number
Q9Y6K1
Host
Rabbit
Reactivity
Human
Immunogen
This DNMT3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from the Central region of human DNMT3A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
102 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DNMT3A
NCBI Official Name
DNA (cytosine-5) -methyltransferase 3A
NCBI Organism
Homo sapiens
Background Reference 01
Holz-Schietinger, C., et al. J. Biol. Chem. 285 (38) :29091-29100 (2010)
Background Reference 02
Kelemen, L.E., et al. Cancer Epidemiol. Biomarkers Prev. 19 (7) :1822-1830 (2010)
Background Reference 03
Park, C.W., et al.Cardiovasc Transl Res 3 (3) :290-295 (2010)
Background Reference 04
Haggarty, P., et al. PLoS ONE (6), E11329 (2010) :
Other Product Names
DNA (cytosine-5) -methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, MHsaIIIA, DNMT3A
Tested Applications
WB
Protein ID
166215081
Physical Properties
Liquid

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