Dnmt3a Antibody

• Background :

  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.

• NCBI Gene ID :

  1788

• Swiss Prot :

  Q9Y6K1

• Accession Number :

  Q9Y6K1

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from the Central region of human Dnmt3a.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  102 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  DNMT3A

• NCBI Official Name :

  DNA (cytosine-5) -methyltransferase 3A

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Xie, S., et al., Gene 236 (1) :87-95 (1999) . Robertson, K.D., et al., Nucleic Acids Res. 27 (11) :2291-2298 (1999) .

• Other Product Names :

  DNA (cytosine-5) -methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, MHsaIIIA, DNMT3A

• Tested Applications :

  WB, IHC-P

• Protein ID :

  166215081

• Physical Properties :

  Liquid