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Dnmt2 Antibody

CAT: 0223-55-093Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-093Size:400 µL
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Background
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI Gene ID
1787
Swiss Prot
O14717
Accession Number
O14717
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This Dnmt2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from human Dnmt2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Symbol
TRDMT1
NCBI Official Name
TRNA (cytosine (38) -C (5) ) -methyltransferase
NCBI Organism
Homo sapiens
Background Reference 01
Hermann, A., et al., J. Biol. Chem. 278 (34) :31717-31721 (2003) .
Background Reference 02
Franchina, M., et al., Int. J. Biochem. Cell Biol. 33 (11) :1104-1115 (2001) .
Background Reference 03
Dong, A., et al., Nucleic Acids Res. 29 (2) :439-448 (2001) .
Background Reference 04
Yoder, J.A., et al., Hum. Mol. Genet. 7 (2) :279-284 (1998) .
Other Product Names
TRNA (cytosine (38) -C (5) ) -methyltransferase, DNA (cytosine-5) -methyltransferase-like protein 2, Dnmt2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, MHsaIIP, PuMet, TRDMT1, DNMT2
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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