Dnmt2 Antibody

• Background:

  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.

• NCBI Gene ID:

  1787

• Swiss Prot:

  O14717

• Accession Number:

  O14717

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Dnmt2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from human Dnmt2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TRDMT1

• NCBI Official Name:

  TRNA (cytosine (38) -C (5) ) -methyltransferase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hermann, A., et al., J. Biol. Chem. 278 (34) :31717-31721 (2003) .

• Background Reference 02:

  Franchina, M., et al., Int. J. Biochem. Cell Biol. 33 (11) :1104-1115 (2001) .

• Background Reference 03:

  Dong, A., et al., Nucleic Acids Res. 29 (2) :439-448 (2001) .

• Background Reference 04:

  Yoder, J.A., et al., Hum. Mol. Genet. 7 (2) :279-284 (1998) .

• Other Product Names:

  TRNA (cytosine (38) -C (5) ) -methyltransferase, DNA (cytosine-5) -methyltransferase-like protein 2, Dnmt2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, MHsaIIP, PuMet, TRDMT1, DNMT2

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid