DNMT2-IN-1

• Description:

  DNMT2-IN-1 (compound 80) is a potent and selective DNMT2 (DNA methyltransferase 2) inhibitor with an IC50 value of 1.2 μM, and has the potential for mental and metabolic disorders or cancer research[1].

• UNSPSC:

  12352211

• Target:

  DNA Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dnmt2-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@H](C(O)=O)CCN(S(=O)(C1=CC([N+]([O-])=O)=C(Br)C=C1)=O)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(N=C3)C(N)=NC=N4)O)O.O=C(O)C(F)(F)F.[3/2]

• Molecular Formula:

  C20H23BrN8O9S.3/2C2HF3O2

• Molecular Weight:

  803.45

• References & Citations:

  [1]Schwickert M, Zimmermann RA, Habeck T, et al. Covalent S-Adenosylhomocysteine-Based DNA Methyltransferase 2 Inhibitors with a New Type of Aryl Warhead. ACS Med Chem Lett. 2023;14 (6) :777-787.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported