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DNMT2-IN-1

CAT: 0804-HY-154867Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-154867Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DNMT2-IN-1 (compound 80) is a potent and selective DNMT2 (DNA methyltransferase 2) inhibitor with an IC50 value of 1.2 μM, and has the potential for mental and metabolic disorders or cancer research[1].
UNSPSC
12352211
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dnmt2-in-1.html
Solubility
10 mM in DMSO
Smiles
N[C@H](C(O)=O)CCN(S(=O)(C1=CC([N+]([O-])=O)=C(Br)C=C1)=O)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(N=C3)C(N)=NC=N4)O)O.O=C(O)C(F)(F)F.[3/2]
Molecular Formula
C20H23BrN8O9S.3/2C2HF3O2
Molecular Weight
803.45
References & Citations
[1]Schwickert M, Zimmermann RA, Habeck T, et al. Covalent S-Adenosylhomocysteine-Based DNA Methyltransferase 2 Inhibitors with a New Type of Aryl Warhead. ACS Med Chem Lett. 2023;14 (6) :777-787.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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