ETS2 Antibody

• Background:

  ETS2 contains an ETS DNA-binding domain and belongs to the ETS family. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets2 and its targets play essential roles in endothelial cell function. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. Overexpression of ETS2 is associated with human esophageal squamous cell carcinoma. ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]) .

• NCBI Gene ID:

  2114

• Swiss Prot:

  P15036

• Accession Number:

  NP_005230

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Drosophila

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ETS2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10408 - Fetal Kidney Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ETS2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  53 kDa

• Applications Notes:

  ETS2 antibody can be used for detection of ETS2 by ELISA at 1:312500. ETS2 antibody can be used for detection of ETS2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  ETS2

• NCBI Official Name:

  V-ets avian erythroblastosis virus E26 oncogene homolog 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ge, Y., (2008) Leukemia 22 (3), 521-529 .

• Other Product Names:

  ETS2, ETS2IT1

• Tested Applications:

  ELISA, WB

• Protein ID:

  4885221

• Physical Properties:

  Liquid