ETS2 Antibody

CAT: 0223-31-278Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-31-278Size:100 µL
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Background
ETS2 contains an ETS DNA-binding domain and belongs to the ETS family. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets2 and its targets play essential roles in endothelial cell function. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. Overexpression of ETS2 is associated with human esophageal squamous cell carcinoma. ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]) .
NCBI Gene ID
2114
Swiss Prot
P15036
Accession Number
NP_005230
Host
Rabbit
Reactivity
Human, Mouse, Rat, Drosophila
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ETS2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10408 - Fetal Kidney Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ETS2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
53 kDa
Applications Notes
ETS2 antibody can be used for detection of ETS2 by ELISA at 1:312500. ETS2 antibody can be used for detection of ETS2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ETS2
NCBI Official Name
V-ets avian erythroblastosis virus E26 oncogene homolog 2
NCBI Organism
Homo sapiens
Background Reference 01
Ge, Y., (2008) Leukemia 22 (3), 521-529 .
Other Product Names
ETS2, ETS2IT1
Tested Applications
ELISA, WB
Protein ID
4885221
Physical Properties
Liquid

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