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HFE Antibody

CAT: 0223-29-976Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-29-976Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M) . It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in its gene.The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M) . It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least eleven alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
NCBI Gene ID
3077
Swiss Prot
Q30201-4
Accession Number
NP_620577
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HFE.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store HFE antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
28 kDa, 40 kDa, 28 kDa, 29 kDa, 39 kDa, 30 kDa, 38 kDa, 19 kDa
Applications Notes
HFE antibody can be used for detection of HFE by ELISA at 1:12500. HFE antibody can be used for detection of HFE by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
HFE
NCBI Official Name
Hemochromatosis
NCBI Organism
Homo sapiens
Background Reference 01
Gleeson, D., (2006) Am. J. Gastroenterol. 101 (2), 304-310.
Other Product Names
HFE, HFE1, HH, HLA-H, MGC103790, dJ221C16.10.1, MVCD7, TFQTL2
Tested Applications
ELISA, WB, IHC
Protein ID
21040351
Physical Properties
Liquid

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