HFE2 Antibody

• Background:

  HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin.

• NCBI Gene ID:

  148738

• Swiss Prot:

  Q6ZVN8

• Accession Number:

  Q6ZVN8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-162 amino acids from the Central region of human HFE2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HFE2

• NCBI Official Name:

  Hemojuvelin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhu, X., et al. Genet. Epidemiol. 34 (2) :171-187 (2010)

• Background Reference 02:

  Barton, J.C., et al. Am. J. Hematol. 84 (11) :710-714 (2009)

• Background Reference 03:

  Zhang, A.S., et al. J. Biol. Chem. 284 (34) :22580-22589 (2009)

• Other Product Names:

  Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC

• Tested Applications:

  WB, IHC-P

• Protein ID:

  51316254

• Physical Properties:

  Liquid