HFE2 Antibody

• Background:

  HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH) . JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

• NCBI Gene ID:

  148738

• Swiss Prot:

  Q6ZVN8

• Accession Number:

  Q6ZVN8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-338 amino acids from the C-terminal region of human HFE2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HFE2

• NCBI Official Name:

  Hemojuvelin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Zhu, X., et al. Genet. Epidemiol. 34 (2) :171-187 (2010)

• Background Reference 02:

  Barton, J.C., et al. Am. J. Hematol. 84 (11) :710-714 (2009)

• Background Reference 03:

  Zhang, A.S., et al. J. Biol. Chem. 284 (34) :22580-22589 (2009)

• Other Product Names:

  Hemojuvelin, Hemochromatosis type 2 protein, RGM domain family member C, HFE2, HJV, RGMC

• Tested Applications:

  WB, Flow

• Protein ID:

  51316254

• Physical Properties:

  Liquid