LEFTY2 Antibody

• Background:

  LEFTY2 is a member of the TGF-beta family of proteins. The protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in its gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of its gene in the endometrium.This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

• NCBI Gene ID:

  7044

• Swiss Prot:

  O00292

• Accession Number:

  NP_003231

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human LEFTY2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction, Growth Factors

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  RPMI 8826 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store LEFTY2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  40 kDa

• Applications Notes:

  LEFTY2 antibody can be used for detection of LEFTY2 by ELISA at 1:312500. LEFTY2 antibody can be used for detection of LEFTY2 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  LEFTY2

• NCBI Official Name:

  Left-right determination factor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Cornet, P.B., (2005) J. Clin. Endocrinol. Metab. 90 (2), 1001-1011.

• Other Product Names:

  LEFTY2, EBAF, LEFTA, LEFTYA, MGC46222, TGFB4

• Tested Applications:

  ELISA, WB

• Protein ID:

  27436881

• Physical Properties:

  Liquid