TSHR Antibody

• Background:

  TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5) .

• NCBI Gene ID:

  7253

• Swiss Prot:

  P16473

• Accession Number:

  NP_000360

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Dog

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TSHR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Membrane, Cancer, Signal Transduction, Immunology

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TSHR antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  84 kDa

• Applications Notes:

  TSHR antibody can be used for detection of TSHR by ELISA at 1:312500. TSHR antibody can be used for detection of TSHR by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  TSHR

• NCBI Official Name:

  Thyroid stimulating hormone receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Claus, M., (2005) Endocrinology 146 (12), 5197-5203.

• Other Product Names:

  TSHR, LGR3, MGC75129, hTSHR-I, CHNG1

• Tested Applications:

  ELISA, WB

• Protein ID:

  64085121

• Physical Properties:

  Liquid