TSHR beta chain Antibody [SPM222]

• Background:

  Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

• NCBI Gene ID:

  7253

• Swiss Prot:

  P16473

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant human TSHR beta chain protein was used as the immunogen for this TSH Receptor antibody.

• Clonality:

  Monoclonal

• Clone:

  SPM222

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Membrane, Cancer, Signal Transduction, Immunology

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG2a

• Symbol:

  TSHR

• NCBI Official Name:

  Thyroid stimulating hormone receptor

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  TSHR, LGR3, MGC75129, hTSHR-I, CHNG1

• Tested Applications:

  Flow, IF, IHC-P

• Physical Properties:

  Liquid