MBD2 Antibody

CAT: 0223-29-201Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-29-201Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MBD2 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD2 can also repress transcription from methylated gene promoters. MBD2 may function as a mediator of the biological consequences of the methylation signal.It is also reported that the MBD2 functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD) . Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
NCBI Gene ID
8932
Swiss Prot
Q9UBB5-3
Accession Number
NP_056647
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MBD2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MBD2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
32 kDa
Applications Notes
MBD2 antibody can be used for detection of MBD2 by ELISA at 1:1562500. MBD2 antibody can be used for detection of MBD2 by western blot at 0.625 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
MBD2
NCBI Official Name
Methyl-CpG binding domain protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Le (2006) Mol. Cell. Biol. 26 (3), 843-851.
Other Product Names
MBD2, DMTase, NY-CO-41
Tested Applications
ELISA, WB
Protein ID
7710145
Physical Properties
Liquid

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