THRB Antibody

CAT: 0223-28-322Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-28-322Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH) . Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far.
NCBI Gene ID
7068
Swiss Prot
P10828
Accession Number
NP_000452
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human THRB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer, Signal Transduction
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store THRB antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
53 kDa
Applications Notes
THRB antibody can be used for detection of THRB by ELISA at 1:1562500. THRB antibody can be used for detection of THRB by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
THRB
NCBI Official Name
Thyroid hormone receptor, beta
NCBI Organism
Homo sapiens
Background Reference 01
Horkko, T.T., et al., (2006) Int. J. Cancer 118 (7), 1653-1659.
Other Product Names
THRB, GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA
Tested Applications
ELISA, WB
Protein ID
40806162
Physical Properties
Liquid

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