CREM Antibody

• Background:

  CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.

• NCBI Gene ID:

  1390

• Swiss Prot:

  O75519

• Accession Number:

  NP_874386

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Dog

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CREM.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Signal Transduction

• Purification:

  Antibody is purified by protein A chromatography method.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CREM antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  13 kDa

• Applications Notes:

  CREM antibody can be used for detection of CREM by ELISA at 1:1562500. CREM antibody can be used for detection of CREM by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  CREM

• NCBI Official Name:

  CAMP responsive element modulator

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kimura, K., et al., (2006) Genome Res. 16 (1), 55-65.

• Other Product Names:

  CREM, ICER, CREM-2, hCREM-2, RP11-324I22.3

• Tested Applications:

  ELISA, WB

• Protein ID:

  34335188

• Physical Properties:

  Liquid