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CREB (Ab 133) Antibody

CAT: 0223-79-293Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-293Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
NCBI Gene ID
1385
Swiss Prot
P16220
Accession Number
NP_004370.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CREB (Ab-133) antibody was raised against a peptide sequence around aa. 131~135 (R-P-S-Y-R) derived from Human CREB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Neuroscience
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
43 kDa
Specificity
This antibody detects endogenous level of total CREB protein and it also detects the CREB-related protein ATF-1.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
CREB1
NCBI Official Name
CAMP responsive element binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Xing J, et al. (1998) Mol Cell Biol 18 (4) : 1946-55. Tan Y, et al. (1996) EMBO J; 15 (17) : 4629-42. Hao, M. et al. (1996) J. Biol. Chem. 271, 29380-29385. Mayo LD, et al. (2001) Biol Chem; 276 (27) : 25184-9. Lu, H. et al. (1997) Mol. Cell. Biol. 17, 5923-5934.
Other Product Names
CREB, NR3C3, CREB-1, CREB1
Tested Applications
WB, IHC
Protein ID
4758054
Physical Properties
Liquid

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