PTK2B Antibody

CAT: 0223-27-668Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-27-668Size:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.
NCBI Gene ID
2185
Swiss Prot
Q14289
Accession Number
NP_004094
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PTK2B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction, Apoptosis
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PTK2B antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
116 kDa
Applications Notes
PTK2B antibody can be used for detection of PTK2B by ELISA at 1:312500. PTK2B antibody can be used for detection of PTK2B by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PTK2B
NCBI Official Name
Protein tyrosine kinase 2 beta
NCBI Organism
Homo sapiens
Background Reference 01
Ling, S., et al., (2004) Am. J. Physiol., Cell Physiol. 287 (3), C698-C706.
Other Product Names
PTK2B, PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK
Tested Applications
ELISA, WB
Protein ID
27886584
Physical Properties
Liquid

Related Products

CatalogName
63-548PTK2 Antibody
63-547PTK2 Antibody
48-192PTK2 Antibody
57-748Mouse Ptk2 Antibody
64-160WAS Antibody
13-349WAS Antibody
60-596WAS Antibody
7095-01FOXH1 Antibody
27-670MEOX1 Antibody
27-665IRF4 Antibody

Alternative Products

CatalogName
70R-19631PTK2B antibody

Popular Products