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ESR1 Antibody

CAT: 0223-26-058Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-26-058Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Hairy/enhancer of split-related proteins, such as HEY1, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
NCBI Gene ID
2099
Swiss Prot
P03372
Accession Number
NP_000116
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ESR1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cell Cycle, Cancer, Signal Transduction, Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ESR1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
66 kDa
Applications Notes
ESR1 antibody can be used for detection of ESR1 by ELISA at 1:62500. ESR1 antibody can be used for detection of ESR1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ESR1
NCBI Official Name
Estrogen receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Giegling, I., (2008) Psychiatry Res 160 (1), 1-7.
Other Product Names
ESR1, DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1, ESTRR
Tested Applications
ELISA, WB
Protein ID
62821794
Physical Properties
Liquid

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