ESR2 Antibody

• Background:

  This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

• NCBI Gene ID:

  2100

• Swiss Prot:

  Q92731

• Accession Number:

  Q92731

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ESR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-527 amino acids from the C-terminal region of human ESR2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  59 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ESR2

• NCBI Official Name:

  Estrogen receptor beta

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Fang, Y.J., et al. Tumour Biol. 31 (6) :651-658 (2010)

• Background Reference 02:

  Hayes, D.F., et al. Clin. Pharmacol. Ther. 88 (5) :626-629 (2010)

• Background Reference 03:

  Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

• Background Reference 04:

  Wurster, M., et al. Oncol. Rep. 24 (3) :653-659 (2010)

• Other Product Names:

  Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2, ESR2, ESTRB, NR3A2

• Tested Applications:

  WB

• Protein ID:

  6166154

• Physical Properties:

  Liquid