ESR2 Antibody

CAT: 0223-60-629Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-629Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
NCBI Gene ID
2100
Swiss Prot
Q92731
Accession Number
Q92731
Host
Rabbit
Reactivity
Human
Immunogen
This ESR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-527 amino acids from the C-terminal region of human ESR2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
59 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ESR2
NCBI Official Name
Estrogen receptor beta
NCBI Organism
Homo sapiens
Background Reference 01
Fang, Y.J., et al. Tumour Biol. 31 (6) :651-658 (2010)
Background Reference 02
Hayes, D.F., et al. Clin. Pharmacol. Ther. 88 (5) :626-629 (2010)
Background Reference 03
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Background Reference 04
Wurster, M., et al. Oncol. Rep. 24 (3) :653-659 (2010)
Other Product Names
Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2, ESR2, ESTRB, NR3A2
Tested Applications
WB
Protein ID
6166154
Physical Properties
Liquid

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