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SPI1 Antibody

CAT: 0223-25-419Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-25-419Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SPI1 is known to collaborate with multiple transcription factors and to regulate expression of immunoglobulin genes. Lack of SPI1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
6688
Swiss Prot
P17947
Accession Number
NP_003111
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SPI1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription, Cancer
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SPI1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
31 kDa
Applications Notes
SPI1 antibody can be used for detection of SPI1 by ELISA at 1:312500. SPI1 antibody can be used for detection of SPI1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SPI1
NCBI Official Name
Spleen focus forming virus (SFFV) proviral integration oncogene
NCBI Organism
Homo sapiens
Background Reference 01
Crotti, T.N., (2008) J. Cell. Physiol. 215 (3), 636-644.
Other Product Names
SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A
Tested Applications
ELISA, WB
Protein ID
124028517
Physical Properties
Liquid

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