ONECUT2 Antibody

• Background:

  ONECUT2 is a member of the transcription factors of the ONECUT class, whose prototype is hepatocyte nuclear factor (HNF) -6. The distribution of OC-2 mRNA in humans is tissue-restricted, the strongest expression being detected in the liver and skin. ONECUT2 participates in the network of transcription factors required for liver differentiation and metabolism. This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation.

• NCBI Gene ID:

  9480

• Swiss Prot:

  O95948

• Accession Number:

  NP_004843

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ONECUT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  721_B Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ONECUT2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  54 kDa

• Applications Notes:

  ONECUT2 antibody can be used for detection of ONECUT2 by ELISA at 1:1562500. ONECUT2 antibody can be used for detection of ONECUT2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  ONECUT2

• NCBI Official Name:

  One cut homeobox 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rauch, T., (2006) Cancer Res. 66 (16), 7939-7947.

• Other Product Names:

  ONECUT2, MGC120377, MGC120378, OC-2, OC2

• Tested Applications:

  ELISA, WB

• Protein ID:

  119220564

• Physical Properties:

  Liquid