OCRL Antibody

• Background :

  This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants.

• NCBI Gene ID :

  4952

• Swiss Prot :

  Q01968

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human OCRL (NP_001578.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  U-251MG

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 110kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:2000

• Symbol :

  OCRL

• Positive Control 2 :

  A-549

• Positive Control 3 :

  22Rv1

• Positive Control 4 :

  Mouse brain

• Positive Control 5 :

  Mouse lung

• Positive Control 6 :

  Rat brain

• NCBI Official Name :

  Oculocerebrorenal syndrome of Lowe

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  OCRL, NPHL2, OCRL-1, LOCR, OCRL1

• Tested Applications :

  WB

• Physical Properties :

  Liquid