MKL1 Antibody

• Background:

  The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  57591

• Swiss Prot:

  Q969V6

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human MKL1 (NP_065882.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle, Signal Transduction, Stem Cell, Transcription

• Purification:

  Affinity purification

• Positive Control:

  TE-1

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 145kDa

• Fragment:

  IgG

• Symbol:

  MKL1

• Positive Control 2:

  HeLa

• Positive Control 3:

  Mouse lung

• Positive Control 4:

  Rat testis

• NCBI Official Name:

  MKL/myocardin-like protein 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  MKL/myocardin-like protein 1, Megakaryoblastic leukemia 1 protein, Megakaryocytic acute leukemia protein, Myocardin-related transcription factor A, MRTF-A, MKL1, KIAA1438, MAL

• Tested Applications:

  WB, IHC, IF, IP

• Physical Properties:

  Liquid