SETDB2 Antibody

• Background:

  This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  83852

• Swiss Prot:

  Q96T68

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SETDB2 (NP_001153780.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  HL-60

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 82kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  SETDB2

• Positive Control 2:

  Mouse thymus

• Positive Control 3:

  Rat heart

• NCBI Official Name:

  SET domain, bifurcated 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Histone-lysine N-methyltransfera, chronic lymphocytic leukemia deletion region gene 8 protein, OTTHUMP00000018418, KMT1F, DKFZp761J1217, DKFZp586I0123, CLLL8, CLLD8, C13orf4, SET domain, bifurcated 2, SETDB2

• Tested Applications:

  WB

• Physical Properties:

  Liquid