SETD1A Antibody

• Background:

  SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex (Lee and Skalnik, 2005 [PubMed 16253997]) . Also see SET1B (MIM 611055) .

• NCBI Gene ID:

  9739

• Swiss Prot:

  O15047

• Accession Number:

  O15047

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SETD1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 927-956 amino acids from the Central region of human SETD1A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  186 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SETD1A

• NCBI Official Name:

  Histone-lysine N-methyltransferase SETD1A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wu, M., et al. Mol. Cell. Biol. 28 (24) :7337-7344 (2008)

• Background Reference 02:

  Nguyen, P., et al. Mol. Cell. Biol. 28 (21) :6720-6729 (2008)

• Background Reference 03:

  Ansari, K.I., et al. Biochim. Biophys. Acta 1779 (1) :66-73 (2008)

• Background Reference 04:

  Lee, J.H., et al. Mol. Cell. Biol. 28 (2) :609-618 (2008)

• Other Product Names:

  Histone-lysine N-methyltransferase SETD1A, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, hSET1A, Set1/Ash2 histone methyltransferase complex subunit SET1, SETD1A

• Tested Applications:

  WB

• Physical Properties:

  Liquid