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SETDB1 Antibody

CAT: 0223-55-382Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-382Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su (var) 3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities.
NCBI Gene ID
9869
Swiss Prot
Q15047
Accession Number
Q15047
Host
Rabbit
Reactivity
Human
Immunogen
This SETDB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1193-1225 amino acids from the C-terminal region of human SETDB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Zebrafish, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
143 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SETDB1
NCBI Official Name
Histone-lysine N-methyltransferase SETDB1
NCBI Organism
Homo sapiens
Background Reference 01
Ichimura, T., et al., J. Biol. Chem. 280 (14) :13928-13935 (2005) .
Background Reference 02
Sarraf, S.A., et al., Mol. Cell 15 (4) :595-605 (2004) .
Background Reference 03
Wang, H., et al., Mol. Cell 12 (2) :475-487 (2003) .
Background Reference 04
Schultz, D.C., et al., Genes Dev. 16 (8) :919-932 (2002) .
Other Product Names
Histone-lysine N-methyltransferase SETDB1, ERG-associated protein with SET domain, ESET, Histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, Lysine N-methyltransferase 1E, SET domain bifurcated 1, SETDB1, KIAA0067, KMT1E
Tested Applications
WB
Protein ID
25091210
Physical Properties
Liquid

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