SETD2 Antibody

• Background:

  Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

• NCBI Gene ID:

  29072

• Swiss Prot:

  Q9BYW2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 803-1103 of human SETD2 (NP_054878.5) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  NCI-H460

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 300kDa

• Fragment:

  IgG

• Symbol:

  SETD2

• Positive Control 2:

  Mouse brain

• Positive Control 3:

  Mouse kidney

• Positive Control 4:

  Mouse liver

• Positive Control 5:

  Rat brain

• NCBI Official Name:

  SET domain containing 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  SETD2, FLJ16420, FLJ22472, FLJ23184, FLJ45883, HIF-1, HSPC069, HYPB, KIAA1732, KMT3A, SET2, HIP-1, HBP231, p231HBP

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid