PRKAA2 Antibody

• Background:

  The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

• NCBI Gene ID:

  5563

• Swiss Prot:

  P54646

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 343-552 of human PRKAA2 (NP_006243.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy, Cancer, Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  SW620

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 69kDa

• Fragment:

  IgG

• Symbol:

  PRKAA2

• Positive Control 2:

  NCI-H460

• Positive Control 3:

  Mouse brain

• Positive Control 4:

  Mouse heart

• Positive Control 5:

  Rat skeletal muscle

• NCBI Official Name:

  Protein kinase, AMP-activated, alpha 2 catalytic subunit

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PRKAA2, protein kinase, AMP-activated, alpha 2 catalytic subunit, PRKAA, AMPK-alpha-2 chain, AMPK2, AMPK, AMP-activated protein kinase alpha 2 catalytic subunit, 5'-AMP-activated protein kinase, catalytic alpha-2 chain

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid