PRKAB2 Antibody

• Background:

  The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.

• NCBI Gene ID:

  5565

• Swiss Prot:

  O43741

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human PRKAB2 (NP_005390.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy, Cancer, Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  MCF7

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 35kDa

• Fragment:

  IgG

• Symbol:

  PRKAB2

• Positive Control 2:

  Mouse heart

• Positive Control 3:

  Mouse brain

• Positive Control 4:

  Rat brain

• NCBI Official Name:

  Protein kinase AMP-activated non-catalytic subunit beta 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase, beta-2 subunit, AMP-activated protein kinase beta 2 non-catalytic subunit, AMPK beta 2, AMPK beta-2 chain, AMPK subunit beta-2, protein kinase, AMP-activated, beta 2 non-catalytic subunit

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid