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PRKAR2B Antibody

CAT: 0223-58-130Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-130Size:400 µL
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Background
CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq].
NCBI Gene ID
5577
Swiss Prot
P31323
Accession Number
P31323
Host
Rabbit
Reactivity
Human
Immunogen
This PRKAR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-147 amino acids from the Central region of human PRKAR2B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
46 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PRKAR2B
NCBI Official Name
CAMP-dependent protein kinase type II-beta regulatory subunit
NCBI Organism
Homo sapiens
Background Reference 01
Liu, Y.J., et al. Obesity (Silver Spring) (2010) In press :
Background Reference 02
Adkins, D.E., et al. Mol. Psychiatry (2010) In press :
Background Reference 03
Islam, A., et al. J. Biol. Chem. 283 (37) :25364-25371 (2008)
Background Reference 04
Ji, Z., et al. J. Biol. Chem. 283 (32) :21920-21925 (2008)
Other Product Names
CAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B
Tested Applications
WB
Protein ID
206729918
Physical Properties
Liquid

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