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PRKAA1 Antibody

CAT: 0223-30-953Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-30-953Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PRKAA1 belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK) . AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK) . AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
NCBI Gene ID
5562
Swiss Prot
Q13131
Accession Number
NP_996790
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PRKAA1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction, Immunology, Apoptosis
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PRKAA1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
62 kDa
Applications Notes
PRKAA1 antibody can be used for detection of PRKAA1 by ELISA at 1:62500. PRKAA1 antibody can be used for detection of PRKAA1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
PRKAA1
NCBI Official Name
Protein kinase, AMP-activated, alpha 1 catalytic subunit
NCBI Organism
Homo sapiens
Background Reference 01
Hasumi, H., Gene 415 (1-2), 60-67 (2008) .
Other Product Names
PRKAA1, AMPK, AMPKa1, MGC33776, MGC57364
Tested Applications
ELISA, WB
Protein ID
94557299
Physical Properties
Liquid

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