GCA Antibody

• Background :

  This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.

• NCBI Gene ID :

  25801

• Swiss Prot :

  P28676

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GCA (NP_036330.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  HL-60

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 24kDa

• Fragment :

  IgG

• Symbol :

  GCA

• Positive Control 2 :

  HT-29

• Positive Control 3 :

  Mouse kidney

• Positive Control 4 :

  Mouse heart

• NCBI Official Name :

  Grancalcin, EF-hand calcium binding protein

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  GCL, Grancalcin, GCL

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid