GCA Antibody

• Background:

  This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.

• NCBI Gene ID:

  25801

• Swiss Prot:

  P28676

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human GCA (NP_036330.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  HL-60

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 24kDa

• Fragment:

  IgG

• Symbol:

  GCA

• Positive Control 2:

  HT-29

• Positive Control 3:

  Mouse kidney

• Positive Control 4:

  Mouse heart

• NCBI Official Name:

  Grancalcin, EF-hand calcium binding protein

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  GCL, Grancalcin, GCL

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid