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GCAT Antibody

CAT: 0223-56-722Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-722Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.
NCBI Gene ID
23464
Swiss Prot
O75600
Accession Number
O75600
Host
Rabbit
Reactivity
Human
Immunogen
This GCAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-128 amino acids from the N-terminal region of human GCAT.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GCAT
NCBI Official Name
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Jacquot, C., et al. Anticancer Res. 22 (4) :2229-2235 (2002)
Background Reference 02
Edgar, A.J., et al. Eur. J. Biochem. 267 (6) :1805-1812 (2000)
Background Reference 03
Tressel, T., et al. J. Biol. Chem. 261 (35) :16428-16437 (1986)
Other Product Names
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, AKB ligase, Aminoacetone synthase, Glycine acetyltransferase, GCAT, KBL
Tested Applications
WB
Physical Properties
Liquid

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