MCM4 Antibody

• Background :

  The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

• NCBI Gene ID :

  4173

• Swiss Prot :

  P33991

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide of human MCM4

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  Jurkat

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 105kDa

• Fragment :

  IgG

• Symbol :

  MCM4

• Positive Control 2 :

  K-562

• Positive Control 3 :

  Mouse thymus

• NCBI Official Name :

  Minichromosome maintenance complex component 4

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  MCM4, NKCD, CDC21, CDC54, NKGCD, hCdc21, P1-CDC21

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid