COL18A1 Antibody

• Background :

  This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  80781

• Swiss Prot :

  P39060

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human COL18A1 (NP_085059.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  Mouse lung

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 240kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:1000

• Symbol :

  COL18A1

• NCBI Official Name :

  Collagen, type XVIII, alpha 1

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  KS, KNO, KNO1

• Tested Applications :

  WB

• Physical Properties :

  Liquid