CDK4 Antibody

• Background :

  The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

• NCBI Gene ID :

  1019

• Swiss Prot :

  P11802

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide of human CDK4.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  K-562

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 34kDa

• Fragment :

  IgG

• Symbol :

  CDK4

• Positive Control 2 :

  293T

• Positive Control 3 :

  Mouse thymus

• NCBI Official Name :

  Cyclin-dependent kinase 4

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  CDK4, CMM3, PSK-J3

• Tested Applications :

  WB, IHC, IF, IP

• Physical Properties :

  Liquid