DPYD Antibody

• Background :

  The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID :

  1806

• Swiss Prot :

  Q12882

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human DPYD (NP_001153773.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  THP-1

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 112kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:2000

• Symbol :

  DPYD

• Positive Control 2 :

  Mouse liver

• NCBI Official Name :

  Dihydropyrimidine dehydrogenase

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  DHP, DHPDHASE, DPD, dihydropyrimidine dehydrogenase [NADP (+) ], dihydrothymine dehydrogenase, dihydrouracil dehydrogenase

• Tested Applications :

  WB

• Physical Properties :

  Liquid