DPYS Antibody

• Background:

  Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.

• NCBI Gene ID:

  1807

• Swiss Prot:

  Q14117

• Accession Number:

  Q14117

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DPYS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-482 amino acids from the C-terminal region of human DPYS.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  57 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DPYS

• NCBI Official Name:

  Dihydropyrimidinase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kim, H.Y., et al. BMB Rep 43 (8) :547-553 (2010)

• Background Reference 02:

  Van Kuilenburg, A.B., et al. Biochim. Biophys. Acta 1802 (7-8), 639-648 (2010) :

• Background Reference 03:

  Fidlerova, J., et al. Cancer Chemother. Pharmacol. 65 (4) :661-669 (2010)

• Background Reference 04:

  Thomas, H.R., et al. Pharmacogenet. Genomics 18 (1) :25-35 (2008)

• Other Product Names:

  Dihydropyrimidinase, DHP, DHPase, Dihydropyrimidine amidohydrolase, Hydantoinase, DPYS

• Tested Applications:

  WB, IHC-P

• Protein ID:

  3122049

• Physical Properties:

  Liquid