PDE1C Antibody

• Background:

  This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta.

• NCBI Gene ID:

  5137

• Swiss Prot:

  Q14123

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 435-634 of human PDE1C (NP_001177985.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HepG2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 81kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  PDE1C

• Positive Control 2:

  Mouse heart

• Positive Control 3:

  Mouse brain

• Positive Control 4:

  Mouse testis

• Positive Control 5:

  Rat heart

• Positive Control 6:

  Rat brain

• NCBI Official Name:

  Phosphodiesterase 1C, calmodulin-dependent 70kDa

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PDE1A, HCAM1, HSPDE1A, MGC26303, Hcam3

• Tested Applications:

  WB

• Physical Properties:

  Liquid