PDE1B Antibody

• Background:

  Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1B, are calmodulin (see MIM 114180) -dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]) .

• NCBI Gene ID:

  5153

• Swiss Prot:

  Q01064

• Accession Number:

  Q01064

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDE1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467-495 amino acids from the C-terminal region of human PDE1B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  61 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PDE1B

• NCBI Official Name:

  Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Talmud, P.J., et al. Am. J. Hum. Genet. 85 (5) :628-642 (2009)

• Background Reference 03:

  Vandeput, F., et al. J. Biol. Chem. 282 (45) :32749-32757 (2007)

• Background Reference 04:

  Bender, A.T., et al. Proc. Natl. Acad. Sci. U.S.A. 103 (2) :460-465 (2006)

• Other Product Names:

  Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, Cam-PDE 1B, 63 kDa Cam-PDE, PDE1B, PDE1B1, PDES1B

• Tested Applications:

  WB

• Protein ID:

  3183514

• Physical Properties:

  Liquid