HSD17B8 Antibody

• Background:

  In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.

• NCBI Gene ID:

  7923

• Swiss Prot:

  Q92506

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human HSD17B8 (NP_055049.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Growth Factors, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  HepG2

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 27kDa

• Fragment:

  IgG

• Symbol:

  HSD17B8

• Positive Control 2:

  BxPC-3

• Positive Control 3:

  U-87MG

• Positive Control 4:

  HeLa

• Positive Control 5:

  Mouse liver

• Positive Control 6:

  Mouse pancreas

• NCBI Official Name:

  Hydroxysteroid 17-beta dehydrogenase 8

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9, estradiol 17-beta-dehydrogenase 8, 17-beta-HSD 8, 17-beta-hydroxysteroid dehydrogenase 8, 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit, 3-oxoacyl-[acyl-carrier-protein] reductase, KAR alpha subunit, estrogen 17-oxidoreductase, ke-6, protein Ke6, really interesting new gene 2 protein, short chain dehydrogenase/reductase family 30C member 1, testosterone 17-beta-dehydrogenase 8

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid