HDAC8 Antibody, KO Validated

• Background:

  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  55869

• Swiss Prot:

  Q9BY41

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human HDAC8 (NP_060956.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Antibody is Knockout validated.

• Field of Research:

  Immunology, Stem Cell

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 42kDa

• Fragment:

  IgG

• Symbol:

  HDAC8

• Positive Control 2:

  Mouse lung

• NCBI Official Name:

  Histone deacetylase 8

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  HDAC8, HDACL1, RPD3, HD8, WTS, CDA07, CDLS5, MRXS6

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid