ARRB1 Antibody

• Background:

  Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

• NCBI Gene ID:

  408

• Swiss Prot:

  P49407

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 169-418 of human ARRB1 (NP_004032.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  U-937

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 56kDa

• Fragment:

  IgG

• Symbol:

  ARRB1

• Positive Control 2:

  K-562

• Positive Control 3:

  Mouse brain

• Positive Control 4:

  Mouse spleen

• NCBI Official Name:

  Beta-arrestin-1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Beta-arrestin-1, Arrestin beta-1, ARRB1, ARR1

• Tested Applications:

  WB, IHC, IF, IP

• Physical Properties:

  Liquid