ARRB1 Antibody

• Background:

  Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.

• NCBI Gene ID:

  408

• Swiss Prot:

  P49407

• Accession Number:

  P49407

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ARRB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-363 amino acids from the C-terminal region of human ARRB1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  47 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ARRB1

• NCBI Official Name:

  Beta-arrestin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shukla, A.K., et al. J. Biol. Chem. 285 (39) :30115-30125 (2010)

• Background Reference 02:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 03:

  Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395 (2) :185-189 (2010)

• Background Reference 04:

  Kim, J.I., et al. Mol. Cancer Res. 8 (4) :569-577 (2010)

• Other Product Names:

  Beta-arrestin-1, Arrestin beta-1, ARRB1, ARR1

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  20141238

• Physical Properties:

  Liquid