PGAM5 (CT) Antibody

• Background:

  PGAM5 Antibody: PGAM5 is a central mediator for programmed necrosis induced by TNF and may be a regulator of mitochondrial dynamics. It displays phosphatase activity for serine/threonine residues, dephosphorylates and activates MAP3K5 kinase. It has apparently no phosphoglycerate mutase activity and is a substrate for a KEAP1-dependent ubiquitin ligase complex. It is also contributes to the repression of NFE2L2-dependent gene expression

• NCBI Gene ID:

  192111

• Swiss Prot:

  Q96HS1

• Accession Number:

  Q96HS1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  9517

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  PGAM5 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1203 – A549 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: gorilla (100%) ; Chimpanzee (100%) ; monkey (100%) .

• Buffer:

  PGAM5 Antibody is supplied in PBS containing 0.02% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PGAM5 antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Isoform:

  Human PGAM5 has 2 isoforms, including isoform 1 (289aa, 32kD), and isoform 2 (255aa, 28kD) . Mouse PGAM5 has 2 isoforms, including isoform 1 (288aa, 32kD) and isoform 2 (287aa, 31.9kD) . Rat PGAM5 has one isoform (288aa, 32kD) . 9517 can detect PGAM5 in human, mouse and rat

• Symbol:

  PGAM5

• Positive Control 2:

  Cat. No. 1282 – 3T3/NIH Cell Lysate

• Positive Control 3:

  Cat. No. 1403 – Mouse Brain Lysate

• NCBI Official Name:

  PGAM family member 5, mitochondrial serine/threonine protein phosphatase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lo S. et al. Exp. Cell Res. 2018; 314 (8) : 1789-1803

• Background Reference 02:

  Takeda et al. PNAS 2009; 106 (30) : 12301-12305

• Background Reference 03:

  Want et al. Cell 2012; 148 (1-2) ; 228-243

• Other Product Names:

  Serine/threonine-protein phosphatase PGAM5 mitochondrial, Bcl-XL-binding protein v68, Phosphoglycerate mutase family member 5

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  150417955

• Physical Properties:

  Liquid