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PGAM5 (CT) Antibody

CAT: 0223-9517-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-9517-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PGAM5 Antibody: PGAM5 is a central mediator for programmed necrosis induced by TNF and may be a regulator of mitochondrial dynamics. It displays phosphatase activity for serine/threonine residues, dephosphorylates and activates MAP3K5 kinase. It has apparently no phosphoglycerate mutase activity and is a substrate for a KEAP1-dependent ubiquitin ligase complex. It is also contributes to the repression of NFE2L2-dependent gene expression
NCBI Gene ID
192111
Swiss Prot
Q96HS1
Accession Number
Q96HS1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
9517
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
PGAM5 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1203 – A549 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: gorilla (100%) ; Chimpanzee (100%) ; monkey (100%) .
Buffer
PGAM5 Antibody is supplied in PBS containing 0.02% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PGAM5 antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human PGAM5 has 2 isoforms, including isoform 1 (289aa, 32kD), and isoform 2 (255aa, 28kD) . Mouse PGAM5 has 2 isoforms, including isoform 1 (288aa, 32kD) and isoform 2 (287aa, 31.9kD) . Rat PGAM5 has one isoform (288aa, 32kD) . 9517 can detect PGAM5 in human, mouse and rat
Symbol
PGAM5
Positive Control 2
Cat. No. 1282 – 3T3/NIH Cell Lysate
Positive Control 3
Cat. No. 1403 – Mouse Brain Lysate
NCBI Official Name
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
NCBI Organism
Homo sapiens
Background Reference 01
Lo S. et al. Exp. Cell Res. 2018; 314 (8) : 1789-1803
Background Reference 02
Takeda et al. PNAS 2009; 106 (30) : 12301-12305
Background Reference 03
Want et al. Cell 2012; 148 (1-2) ; 228-243
Other Product Names
Serine/threonine-protein phosphatase PGAM5 mitochondrial, Bcl-XL-binding protein v68, Phosphoglycerate mutase family member 5
Tested Applications
ELISA, WB, IF
Protein ID
150417955
Physical Properties
Liquid

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