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POLRMT (CT) Antibody

CAT: 0223-9561-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-9561-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
POLRMT Antibody: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. POLRMT mutations impair mitochondrial transcription causing neurological disease. Knock-down of MRPL12 by RNA interference results in instability of POLRMT.
NCBI Gene ID
5442
Swiss Prot
O0411
Accession Number
O0411.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
9561
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
POLRMT Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1203 - A549 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Cow (82%) ; Chimpanzee (100%) ; monkey (82%) ; Cat (90%)
Buffer
POLRMT Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
POLRMT antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human POLRMT has 1 isoform (1230aa, 138.6kD) . Mouse POLRMT has one isoform (1207aa, 136.7kD) . Rat POLRMT has one isoform (1203aa, 135.8kD) . 9561 can detect POLRMT in human, mouse and rat.
Symbol
POLRMT
Positive Control 2
Cat. No. 1224 - Daudi Cell Lysate
NCBI Official Name
RNA polymerase mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Inatomi et al. Biochim Biophys Acta Mol Cell Res. 2022; 1869 (1) ; 119167
Background Reference 02
Olahova et al. Nat Commun. 2021; 12 (1) :1135
Background Reference 03
Nouws et al. J Biol Chem 2016; 291 (2) :989-997
Other Product Names
DNA-directed RNA polymerase, mitochondrial, MtRPOL, POLRMT Isoforms
Tested Applications
ELISA, WB, IF
Protein ID
50403691
Physical Properties
Liquid

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