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AIFM2 (CT) Antibody

CAT: 0223-9653-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-9653-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
AIFM2 Antibody: AIFM2 blocks ferroptosis independent of ubiquinol metabolism. AIFM2 is a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway. AIFM2 confers protection against ferroptosis elicited by GPX4 deletion. AIF-2 was found to be upregulated in human glioma tissues and cell lines. Downregulation of AIF-2 reduced cell proliferation and induced G1 cell cycle arrest. AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type) . AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro) viral) cytosolic DNA, thus contributing to the onset of apoptosis
NCBI Gene ID
84883
Swiss Prot
Q9BRQ8
Accession Number
Q9BRQ8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
9653
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
AIMF2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 – HeLa Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Gorilla (100%) ; chimpanzee (100%), cow (92%), Horse (92%)
Buffer
AIFM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
AIMF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Applications Notes
WB: 2 μ g/mL; IHC: 1 μ g/mL; IF: 20 μ g/mL. Antibody validated: Western Blot in human, mouse and rat samples; Immunofluorescence in human samples and Immunohistochemistry in human mouse and rat samples. All other applications and species not yet tested.
Isoform
Human AIFM2 has 2 isoforms, including isoform 1 (373aa, 40.5kD) and isoform 2 (336aa, 36.5kD) . Mouse AIFM2 has 2 isoforms, isoform 1 (373aa, 40.6kD) and isoform 2 (380aa, 41.4kD) . Rat AIFM2 has one isoform (373aa, 40.7kD) . 9653 can detect AIFM2 in human, mouse and rat.
Symbol
AIMF2
Positive Control 2
Cat. No. 17-001 – HeLa Cell Slide
NCBI Official Name
Apoptosis inducing factor mitochondria associated
NCBI Organism
Homo sapiens
Background Reference 01
Dai et al. Biochem Biophys Res Commun. 2020; 523 (4) :966-971
Background Reference 02
Bersuker et al. Nature 2019; 575 (7784) :688-692
Background Reference 03
Doll et al. Nature 2019; 575 (7784) :693-698
Background Reference 04
Chen et al. J Mol Neurosci 2019; 68 (2) : 304-310
Background Reference 05
Gong et al. J Biol Chem 2007; 282 (41) :30331-30340
Other Product Names
AIMF2
Tested Applications
ELISA, IHC, WB
Protein ID
74752283
Physical Properties
Liquid

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