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RLN3 Antibody

CAT: 0223-8181-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8181-01Size:0.02 mg
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Background
Relaxin-3 (RLN3) is a member of Relaxin family, a group of endocrine and autocrine/paracrine hormones that belong to the insulin gene superfamily (1,2) . RLN3 can bind to and activate three relaxin-family peptide receptors: RXFP1, RXFP3, and RXFP4 (3) . In contrast to the widespread expression of the related proteins RLN1 and RLN2, RLN3 is predominantly expressed in brain and to a lesser extent in the thymus, kidney and spleen (1) . RLN3 has been suggested to play a role in feeding, metabolism, stress, arousal, learning, and memory (4) .
NCBI Gene ID
117579
Swiss Prot
Q8WFX3
Accession Number
NP_543140
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Neuroscience
Purification
RLN3 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (89%), Rat: (84%)
Buffer
RLN3 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RLN3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
RLN3 antibody is human specific. RLN3 antibody is predicted to not cross-react with other members of the Relaxin protein family.
Symbol
RLN3
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Relaxin 3
NCBI Organism
Homo sapiens
Background Reference 01
Bathgate RA, Samuel CS, Burazin TC, et al. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J. Biol. Chem. 2002; 277:1148-57.
Background Reference 02
Wilkinson TN and Bathgate RA. The evolution of the relaxin peptide family and their receptors. Adv. Exp. Med. Biol. 2007; 612:1-13.
Background Reference 03
Silvertown JD, Neschadim A, Liu HN, et al. Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. Regul. Pept. 2010; 159:44-53.
Background Reference 04
Bathgate RAD, Halls ML, van der Westhuizen ET, et al. Relaxin family peptides and their receptors. Physiol. Rev. 2012; 93:405-80.
Other Product Names
Relaxin-3, RXN3, H3, ZINS4, INSL7
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
18254464
Physical Properties
Liquid

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